Cyclophilin Inhibitors Remodel the Endoplasmic Reticulum of HCV-Infected Cells in a Unique Pattern Rendering Cells Impervious to a Reinfection.
The mechanisms of action by which cyclophilin inhibitors (CypI) interfere with the HCV life Bento Box cycle remain poorly understood.We reported that CypI and NS5A inhibitors (NS5Ai), but not other classes of anti-HCV agents, prevent assembly of double membrane vesicles (DMVs), which protect replication complexes.We demonstrated that both NS5A and