CYCLOPHILIN INHIBITORS REMODEL THE ENDOPLASMIC RETICULUM OF HCV-INFECTED CELLS IN A UNIQUE PATTERN RENDERING CELLS IMPERVIOUS TO A REINFECTION.

Cyclophilin Inhibitors Remodel the Endoplasmic Reticulum of HCV-Infected Cells in a Unique Pattern Rendering Cells Impervious to a Reinfection.

The mechanisms of action by which cyclophilin inhibitors (CypI) interfere with the HCV life Bento Box cycle remain poorly understood.We reported that CypI and NS5A inhibitors (NS5Ai), but not other classes of anti-HCV agents, prevent assembly of double membrane vesicles (DMVs), which protect replication complexes.We demonstrated that both NS5A and

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Effects of removing a fee-for-service incentive on specialist chronic disease services: a time-series analysis

IntroductionPhysician payment models are known to affect the nature and volume of services provided.Our objective was to study the effects of removing a financial incentive, the fee-for-service premium, on the provision of chronic disease follow-up services by internal medicine, cardiology, nephrology and gastroenterology specialists.MethodsWe coll

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Curved Structure of Si by Improving Etching Direction Controllability in Magnetically Guided Metal-Assisted Chemical Etching

Metal-assisted chemical etching (MACE) is widely used to fabricate micro-/nano-structured Si owing to its simplicity and cost-effectiveness.The technique of magnetically guided MACE, involving MACE with a tri-layer metal catalyst, was developed to improve etching speed as well as to adjust the etching direction using an external magnetic field.Howe

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